WILD BLUEBERRY FRUIT EXTRACT

Brain function

Supports memory in adults [3–5]

Supports memory and cognitive performance in children [6–9]

Supports mood [10]

Supports task-related brain activation [11]

Supports memory (animal studies) [12–15]

Supports dopaminergic neurotransmission [16–18]

Supports brain-derived neurotrophic factor (BDNF) [14,15,19–21]

Supports hippocampal IGF-1 levels [22]

Supports long-term potentiation (LTP) [23]

Supports neuroprotective functions [22,24,25]

Supports healthy brain aging [18,26,27]

Supports brain circulation [11]

Antioxidant defenses

Supports antioxidant enzymes in the brain (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) [28–30]

Replenishes glutathione (GSH) [31]

Downregulates NADPH oxidase activity [32]

Supports free radical scavenging and antioxidant functions [28,33–35]

Cardiometabolic health

Supports cardiac function [36]

Supports vascular function [37]

Supports cardio-protective functions [38]

Supports endothelial nitric oxide (eNOS) activity [31]

Supports healthy blood pressure [3,28,39–41]

Downregulates LDL oxidation [35,39]

Supports healthy blood glucose levels [42]

Vision

Protects retinal photoreceptor cells from blue LED light-induced damage [43,44]

Protects against screen-induced ocular fatigue [45,46]

Exercise performance

Supports exercise performance [47]

Supports recovery from muscle damage [48]

Gut Microbiota

Supports the composition of the gut microbiota [49–56]

Supports microbial metabolism — short-chain fatty acid (SCFA) production [57]

Supports the intestinal epithelial barrier [52]

Healthy aging and longevity

Supports stem cell proliferation [58]

Prevents cell senescence [59]

Supports nuclear factor erythroid-2 related factor-2 (Nrf2) [29,30]

Supports DNA repair enzymes [29]

Protects against DNA damage [60–62]

Extends lifespan (Drosophila melanogaster) [63]

Immune System 

Supports innate immune system [37,64–68]

Supports adaptive immune system [69]

Supports immune system communication [68,70,71]

Synergies

With grape extracts for support of cognitive function [72–75]

With grape extracts for blueberry/grape polyphenol bioavailability [76]

With green tea and soy protein for general immune health [77]

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